Inflammation enhances epileptogenesis in the developing rat brain

Role of Brain Inflammation in Epileptogenesis

Inflammation is known to participate in the mediation of a growing number of acute and chronic neurological disorders. Even so, the involvement of inflammation in the pathogenesis of epilepsy and seizure-induced brain damage has only recently been appreciated. Inflammatory processes, including activation of microglia and astrocytes and production of proinflammatory cytokines and related molecul...

The Role of Brain Inflammation in Epileptogenesis in TSC

PET imaging of brain inflammation during early epileptogenesis in a rat model of temporal lobe epilepsy

UNLABELLED BACKGROUND Recently, inflammatory cascades have been suggested as a target for epilepsy therapy. Positron emission tomography (PET) imaging offers the unique possibility to evaluate brain inflammation longitudinally in a non-invasive translational manner. This study investigated brain inflammation during early epileptogenesis in the post-kainic acid-induced status epilepticus (KA...

Inflammation independent epileptogenesis in vitro

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CNS Inflammation and Epileptogenesis

An association between acute CNS infections and seizures is reported in the literature. The etiology of these seizures is, in some cases, precipitated by epileptogenic pathogenesis of the infectious agent in the brain parenchyma. A different etiology of seizures as a consequence of infections, independent of the infectious agent, relates to the inflammatory reaction. Thirdly, the febrile respon...